Board of Trustees of University of Illinois (Urbana, IL)
International Classification
H01M 214
U.S. Classification
429 38, 429 12, 429 13, 429 17
Abstract
An electrochemical cell is described that includes (a) a first electrode; (b) a second electrode; and (c) a channel contiguous with at least a portion of the first and the second electrodes. When a first liquid is contacted with the first electrode, a second liquid is contacted with the second electrode, and the first and the second liquids flow through the channel, a parallel laminar flow is established between the first and the second liquids. Electronic devices containing such electrochemical cells and methods for their use are also described.
Claim
What is claimed is: 1. An electrochemical cell comprising: a first electrode a second electrode; and a channel contiguous with at least a portion of the first and the second electrodes; such that when a first liquid is contacted with the first electrode, a second liquid is contacted with the second electrode, and the first and the second liquids flow through the channel, a parallel laminar flow is established between the first and the second liquids, and a current density of at least 0. 1 mA/cm2is produced. 2. The electrochemical cell of claim 1 wherein the channel comprises a first input adjacent to the first electrode, and a second input adjacent to the second electrode. 3. The electrochemical cell of claim 2 wherein the first liquid is introduced through the first input, and the second liquid is introduced through the second input. 4. The electrochemical cell of claim 3 wherein the first liquid is introduced through the first input using a first pump, and the second liquid is introduced through the second input using a second pump. 5. The electrochemical cell of claim 3 wherein the first liquid is introduced through the first input at a first flow rate, the second liquid is introduced through the second input at a second flow rate, and the first flow rate and the second flow rate are similar. 6.
Electrochemical Cells Comprising Laminar Flow Induced Dynamic Conducting Interfaces, Electronic Devices Comprising Such Cells, And Methods Employing Same
The Board of Trustees of the University of Illinois (Urbana, IL)
International Classification
H01M 8/00, H01M 8/04, H01M 8/24, H01M 2/14
U.S. Classification
429 12, 429 17, 429 18, 429 38
Abstract
An electrochemical cell is described that includes (a) a first electrode; (b) a second electrode; and (c) a channel contiguous with at least a portion of the first and the second electrodes. When a first liquid is contacted with the first electrode, a second liquid is contacted with the second electrode, and the first and the second liquids flow through the channel, a parallel laminar flow is established between the first and the second liquids. Electronic devices containing such electrochemical cells and methods for their use are also described.
High Efficiency Fuel Cell System
Application
#8163429 Apr 24, 2012
Filed
Feb 5, 2009
Inventor
Larry J. Markoski (Raleigh, NC) ·
Dilip Natarajan (Cary, NC)
Appl. No.
12/366529
Assignee
INI Power Systems, Inc. (Cary, NC)
International Classification
H01M 8/06
U.S. Classification
429448, 429443, 429447, 429428, 429408, 429415
Abstract
A fuel cell comprises an anode comprising an anode catalyst, a cathode comprising a gas diffusion electrode and a cathode catalyst on the gas diffusion electrode, a microfluidic channel contiguous with the anode, and a liquid comprising fuel in the channel. The concentration of the fuel in the liquid is 0. 05-0. 5 M.
The Board of Regents acting for and on behalf of University of Michigan (Ann Arbor, MI)
International Classification
C07C20512
U.S. Classification
560360
Abstract
Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ting; and X and Y are carbox amino, alcohol, isocyanate, acid halide, or bis-acyl fluoride groups. In a particularly preferred embodiment, the cyclobutabenzene derivative is 1,2-dihydrocyclobutabenzene-3,6-carboxylic acid. The difunctionalized cyclobutabenzene monomer can form part of a polymer backbone chain, but has an additional functionality, the butane ring, which can be easily opened to produce strong, covalent bond crosslinking between polymer chains. The crosslinking can be induced simply by heating the polymer to a temperature in excess of 300. degree. C.
Difunctional Bitricyclodecatriene Monomers
Method And Apparatus For Efficient Fuel Consumption
A method for efficient fuel consumption comprises recharging batteries or operating a device carrying out a task, with an engine through an electrical connection. The method also includes monitoring at least one of (i) current in the electrical connection, (ii) voltage of the batteries, and (iii) length of time of the recharging or task, to determine if the recharging has reach a preselected endpoint or the task has been completed. The method further includes generating a signal through a communication link to cause the engine to stop operating by: (a) preventing operation of a spark plug, (b) preventing delivery of fuel to the engine, or (c) preventing delivery of oxygen to the engine.
Method And Apparatus For Enhancing Power Density Of Direct Liquid Fuel Cells
Application
#2012030 Nov 29, 2012
Filed
Dec 22, 2011
Inventor
Larry J. Markoski (Raleigh, NC) ·
Dilip Natarajan (Wilmington, DE)
Appl. No.
13/334929
Assignee
Larry J. Markoski (Raleigh, NC) ·
Dilip Natarajan (Wilmington, DE)
International Classification
H01M 8/06, H01M 8/04, H01M 8/22
U.S. Classification
429414, 429506, 429428
Abstract
A fuel cell includes a direct liquid fuel cell and a humidifier. The direct liquid fuel cell includes an air intake channel for providing oxidant to the fuel cell and an exhaust channel for exhausting depleted oxidant. The humidifier forms a fluid connection between the air intake channel and the exhaust channel.
An electrochemical cell comprises a first electrode, a second electrode, a porous separator, between the first and second electrodes, a first channel, having an inlet and an outlet, and a second channel, having an inlet and an outlet. The first channel is contiguous with the first electrode and the porous separator, and the second channel is contiguous with the second electrode and the porous separator.
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
Claim
What is claimed is: 1. A compound of Formula I or a pharmaceutically acceptable salt thereof wherein R1 is H, a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R2 is H, a straight or branched alkyl of 1-5 carbons; R3 is H, (CR′2)nOR, (CR′2)nN(R)2, (CR′2)nNR′COR, (CR′2)nCO2R, (CR′2)nOCOR, (CR′2)nCON(R)2, (CR′2)nOCON(R)2, (CR′2)nR, (CR′2)nNR′CON(R)2, (CR′2)nNR′CO2R, (CR′2)nOSO2N(R)2, (CR′2)nNR′SO20R, (CR′2)nNR′SO2N(R)2, (CR′2)nOSO2R, (CR′2)nNR′SO2R, (CR′2)nSOpR, (CR′2)nNR′CSN(R)2, (CR′2)nNR′C(NR′)N(R)2, (CR′2)nSO2N(R)2, (CR′2)nC(NR′)N(R)2, (CR′2)nCOR, O(CR′2)mOR, NR(CR′2)mOR, F, Cl, Br, CF3, CN, or ═O; R4, R5, and R6 are independently H, a straight or branched alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons, (CR′2)nOR, (CR′2)nN(R)2, F, Cl, Br, CN, CF3, ═O, (CR′2)pNR′COR, (CR′2)pSOpR, (CR′2)pR, (CR′2)pOCOR, O(CR′2)mOR, NR(CR′2)mOR, (CR′2)pNR′CON(R)2, (CR′2)pOCON(R)2, (CR′2)pNR′CO2R, (CR′2)pCOR, (CR′2)pCO2R, (CR′2)pCON(R)2, (CR′2)pNR′SO2R, (CR′2)pSO2N(R)2, (CR′2)pNR′SO2OR, (CR′2)pOSO2N(R)2, (CR′2)pNR′SO2N(R)2, (CR′2)pC(NR′)N(R)2, (CR′2)pNR′C(NR′)N(R)2, (CR′2)pHet; any two of R1-R3 or R4-R6 may together form a ring of 5-6 total atoms which may contain 0-3 heteroatoms; n is an integer of from 0 to 3; m is an integer of from 2 to 4; p is an integer from 0 to 2; R7 is a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R is independently H, a straight or branched alkyl of 1-4 carbons, (CH2)nPh, or a (CH2)nheterocycle of 5-6 atoms containing 1-2 heteroatoms and wherein the (R)2 in N(R)2 may form a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, OR′, CN, CO2R′, N(R′)2, NR′COR′, CF3, or ═O; R′ is independently H, a straight or branched alkyl of 1-4 carbons, or phenyl; R″ is independently H, a straight or branched alkyl of 1-4 carbons, F, Cl, Br, OR′, or N(R′)2; Ar1 is phenyl and Ar2 is Het; wherein Het is a heterocycle of from 5-6 atoms having from 1-4 heteroatoms or a fused heterocycle of from 9-10 atoms having 1-3 heteroatoms Ar2 is Het wherein Het is a heterocycle of from 5-6 atoms having 1-4 heteroatoms selected from furan, pyrrole, thiophene, oxazole, isoxazole, thiazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, tetrazole, pyridine, pyridazine, pyrimidine, or pyrazine, or a fused heterocycle of from 9-10 atoms having from 1-3 heteroatoms selected from: benzofuran, indole, indoline, benzothiophene, benzimidazole, benzthiazole, benzoxazole, quinoline, isoquinoline, cinnoline, quinazoline and quinoxaline. 2. A compound according to claim 1 wherein: R1 is a straight or branched alkyl of from 1 to 4 carbons or a carbocycle of from 3 to 5 carbons and R2 is H or a straight or branched alkyl of from 1 to 3 carbons. 3. A compound according to claim 1 wherein: R1 is isopropyl or t-butyl; R2 is H, methyl, or ethyl; R3 is H, (CR′2)nOR, (CR′2)nN(R)2, (CR′2)nNR′COR, (CR′2)nCO2R, (CR′2)nOCOR, (CR′2)nCON(R)2, (CR′2)nOCON(R)2, (CR′2)nNR′CON(R)2, (CR′2)nNR′CO2R, (CR′2)nOSO2N(R)2, (CR′2)nNR′SO2OR, (CR′2)nNR′SO2N(R)2, (CR′2)nOSO2R, (CR′2)nNR′SO2R, (CR′2)nSOpR, (CR′2)nNR′CSN(R)2, (CR′2)nCOR, O(CR′2)mOR, NR(CR′2)mOR, F, Cl, Br, CF3, CN, or ═O; R4, R5, and R6 are independently H, a straight or branched alkyl of 1-6 carbons, a cycloalkyl of 3-6 carbons, (CH2)nOR, (CH2)nN(R)2, F, Cl, Br, CN, CF3, ═O, (CR′2)pNR′COR, (CR′2)pSOpR, (CR′2)pNR′CON(R)2, (CR′2)pOCON(R)2, (CR′2)pNR′CO2R, (CR′2)pCOR, (CR′2)pCO2R, (CR′2)pCON(R)2, (CR′2)pNR′SO2R, (CR′2)pSO2N(R)2, (CR′2)pNR′SO2OR, (CR′2)pOSO2N(R)2, (CR′2)pHet and any two of R1-R3 or R4-R6 may together form a ring of 5-6 total atoms which may contain 0-2 heteroatoms; n is an integer of 0 to 3; m is an integer of 2 to 4; p is 0 to 2; R7 is a straight or branched alkyl of 1-6 carbons or a carbocycle of 3-6 carbons; R is H, a straight or branched alkyl of 1-4 carbons, (CH2)nPh, or a (CH2)nheterocycle of 5-6 atoms containing 1-2 heteroatoms and wherein the (R)2 in N(R)2 may form a heterocycle containing the nitrogen, all optionally substituted by F, Cl, Br, OR′, N(R′)2, NR′COR′, CF3, or ═O; R′ is H, a straight or branched alkyl of 1-4 carbons, or phenyl; R″ is H, a straight or branched alkyl of 1-4 carbons, F, Cl, Br, OR′, or N(R′)2; Ar1 is phenyl; and Ar2 is Het wherein Het is a heterocycle of from 5-6 atoms having 1-4 heteroatoms selected from: furan, pyrrole, thiophene, oxazole, isoxazole, thiazole, pyrazole, 1,2,3-triazole, 1,2,4-triazole, tetrazole, pyridine, pyridazine, pyrimidine, or pyrazine or a fused heterocycle of from 9-10 atoms having from 1-3 heteroatoms selected from: benzofuran, indole, indoline, benzothiophene, benzimidazole, benzthiazole, benzoxazole, quinoline, isoquinoline, cinnoline, quinazoline and quinoxaline. 4.
Fuel Cells Comprising Laminar Flow Induced Dynamic Conducting Interfaces, Electronic Devices Comprising Such Cells, And Methods Employing Same
The Board of Trustees of the University of Illinois (Urbana, IL)
International Classification
H01M 8/00, H01M 8/04, H01M 8/14, H01M 8/24
U.S. Classification
429 12, 429 17, 429 18, 429 38
Abstract
A fuel cell is described that includes (a) a first electrode; (b) a second electrode; and (c) a channel contiguous with at least a portion of the first and the second electrodes. When a first liquid is contacted with the first electrode, a second liquid is contacted with the second electrode, and the first and the second liquids flow through the channel, a multistream laminar flow is established between the first and the second liquids. Electronic devices containing such electrochemical cells and methods for their use are also described.
Permselective Composite Membrane For Electrochemical Cells
An electrochemical cell includes an anode including an anode catalyst, a cathode including a cathode catalyst, and a first set of proton-conducting metal nanoparticles between the anode and the cathode, such that the first set of proton-conducting metal nanoparticles is not in contact with the anode. The cathode may be a cathode assembly including a gas diffusion electrode, a cathode catalyst on the gas diffusion electrode, and proton-conducting metal nanoparticles on the cathode catalyst.
The Board of Trustees of the University of Illinois (Champaign, IL)
International Classification
C08G 7310
U.S. Classification
528 28
Abstract
Branched or hyperbranched polymeric structures which contain at least one etherimide branch point, more specifically from stable A. sub. 1 B. sub. n (where n. gtoreq. 2), AB, AA, and BB monomers; A. sub. m end-capping agents (where m=1); B. sub. n cores (where n. gtoreq. 1) and combinations thereof; with controllable degrees of branching (DB=0-1), molecular architectures, end-group compositions, along with methods for their preparation.
This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish cytotoxicity further enhancing the desirable properties of these agents as antivirals.
A generator system includes (i) an internal combustion engine, (ii) an exhaust gas outlet, connected to the internal combustion engine, for venting exhaust gasses, and (iii) a condenser, connected to the exhaust gas outlet, for condensing water from exhaust gasses.
Liquid Containers And Apparatus For Use With Power Producing Devices
A fuel reservoir for dispensing liquid fuel with a dispensing appliance includes a container having an opening, a liquid fuel in the container, a needle-pierceable septum disposed across the opening of the container, and a locking surface disposed on an exterior surface of the container and configured to engage a locking mechanism of a dispensing appliance.
A fuel cell includes an anode, a cathode, a microfluidic channel contiguous with at least one of the anode and the cathode, and a single flowing electrolyte. The flowing electrolyte passes through the microfluidic channel. A method of generating electricity includes flowing the single electrolyte through the microfluidic channel, where a fuel is oxidized at the anode, an oxidant is reduced at the cathode, and the electrolyte comprises the fuel or the oxidant. The flowing electrolyte may pass through the microfluidic channel in a laminar flow.
Process For The Preparation Of Polyethylene Glycol Bis Amine
A two step process for the preparation of polyethylene glycol-bis amine comprising a first step of reacting the terminal hydroxy groups of polyethylene glycol with a halogen substituted aromatic sulfonyl halide in a solvent to form a disubstituted sulfonyl activated polyethylene glycol intermediate. In a second step the intermediate is directly aminated with ammonia to give polyethylene glycol-bis amine.
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
The Board of Trustees of the University of Illinois (Urbana, IL)
International Classification
H01M 8/08
U.S. Classification
429 46, 429 40
Abstract
A method for transporting a gas to an electrode in a fuel cell is provided, whereby the gas is dissolved in an emulsion comprising a fluorinated hydrocarbon, a surfactant and an aqueous electrolyte with a pH of at most 4 or at least 9, and the emulsion is contacted with the electrode.
System For Flexible In Situ Control Of Water In Fuel Cells
An electrochemical cell includes an anode, a cathode including a gas diffusion electrode and having first and second surfaces, an inlet for gaseous oxidant that is in contact with the first surface of the cathode, and a liquid electrolyte. Water generated at the cathode may be transported by osmosis into the liquid electrolyte. The fuel cell may produce a current density of 200 mA/cmwithout cathode flooding.
An electrochemical cell comprises a first electrode, a second electrode, a porous separator, between the first and second electrodes, a first channel, having an inlet and an outlet, and a second channel, having an inlet and an outlet. The first channel is contiguous with the first electrode and the porous separator, and the second channel is contiguous with the second electrode and the porous separator.
Electrochemical Cells Comprising Laminar Flow Induced Dynamic Conducting Interfaces, Electronic Devices Comprising Such Cells, And Methods Employing Same
The Board of Trustees of the University of Illinois (Urbana, IL)
International Classification
H01M 8/04
U.S. Classification
429513, 429448, 429498, 429472, 429506
Abstract
An electrochemical cell is described that includes (a) a first electrode; (b) a second electrode; and (c) a channel contiguous with at least a portion of the first and the second electrodes. When a first liquid is contacted with the first electrode, a second liquid is contacted with the second electrode, and the first and the second liquids flow through the channel, a parallel laminar flow is established between the first and the second liquids. Electronic devices containing such electrochemical cells and methods for their use are also described.
A fuel cell includes an anode including an anode catalyst, a cathode, a channel that is contiguous with the anode, and a liquid electrolyte in the channel. The cathode includes a gas diffusion electrode, a cathode catalyst on the gas diffusion electrode, and a hydrogel on the cathode catalyst. The hydrogel is between the anode and the cathode, and includes an aqueous liquid and a polymer. The polymer has an acid capacity less than 0. 8 meq/g and/or has no sulfonic acid groups covalently bound to the polymer. A method of generating electricity includes flowing a liquid electrolyte through the channel, oxidizing a fuel at the anode, and reducing a gaseous oxidant at the cathode.
This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish cytotoxicity further enhancing the desirable properties of these agents as antivirals.
The Board of Regents of the University of Michigan (Ann Arbor, MI)
International Classification
C08G 6300
U.S. Classification
528 68
Abstract
Novel difucntionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl fluoride groups. In a particularly preferred embodiment, the cyclobutabenzene derivative is 1,2-dihydrocyclobutabenzene-3,6-carboxylic acid. The difunctionalized cyclobutabenzene monomer can form part of a polymer backbone chain, but has an additional functionality, the butane ring, which can be easily opened to produce strong, covalent bond crosslinking between polymer chains. The crosslinking can be induced simply by heating the polymer to a temperature in excess of 300. degree. C.
Method And Apparatus For Developing Thin Layer Chromatography Plates For Maximizing Mobile Phase Conditions In Column Chromatography
Application
#6264893 Jul 24, 2001
Filed
Apr 13, 1999
Inventor
Larry J. Markoski (Champaign, IL)
Appl. No.
9/290215
Assignee
Larry J. Markoski (Champaign, IL)
International Classification
G01N 3090
U.S. Classification
422 70
Abstract
An apparatus for conducting multiple thin layer chromatographic processes including an array of receptacles, each receivable of chromatographic fluid, a support structure for supporting the receptacles, and a retaining unit for retaining thin layer chromatographic plates while enabling each plate to be inserted into and removed from a respective receptacle. In use, one or more samples of interest are spotted onto multiple thin layer chromatography plates, the chromatography receptacles are filled with a suitable amount of a chromatography solvent, the plates are inserted into respective chambers to begin the chromatography process and the processes are allowed to continue for a sufficient time period for sample separation to occur. Any separated samples are readily visualized and detected.
Method And Apparatus For Efficient Fuel Consumption
Application
#2015001 Jan 15, 2015
Filed
Jul 21, 2014
Inventor
Larry J. Markoski (Raleigh, NC)
Appl. No.
14/336361
Assignee
Larry J. Markoski (Raleigh, NC)
International Classification
H02J 7/32, H02J 7/00, F02B 63/04
U.S. Classification
290 40 B
Abstract
A method for efficient fuel consumption comprises recharging batteries or operating a device carrying out a task, with an engine through an electrical connection. The method also includes monitoring at least one of (i) current in the electrical connection, (ii) voltage of the batteries, and (iii) length of time of the recharging or task, to determine if the recharging has reach a preselected endpoint or the task has been completed. The method further includes generating a signal through a communication link to cause the engine to stop operating by: (a) preventing operation of a spark plug, (b) preventing delivery of fuel to the engine, or (c) preventing delivery of oxygen to the engine.
Method And Apparatus For Efficient Fuel Consumption
Application
#2013022 Aug 29, 2013
Filed
Feb 29, 2012
Inventor
Larry J. Markoski (Raleigh, NC) ·
Larry J. Markoski (Raleigh, NC)
Appl. No.
13/408903
Assignee
Larry J. Markoski (Raleigh, NC) ·
Larry J. Markoski (Raleigh, NC)
International Classification
H02P 9/04, H02J 7/32
U.S. Classification
290 40 R, 320162
Abstract
A method for efficient fuel consumption comprises recharging batteries or operating a device carrying out a task, with an engine through an electrical connection. The method also includes monitoring at least one of (i) current in the electrical connection, (ii) voltage of the batteries, and (iii) length of time of the recharging or task, to determine if the recharging has reach a preselected endpoint or the task has been completed. The method further includes generating a signal through a communication link to cause the engine to stop operating by: (a) preventing operation of a spark plug, (b) preventing delivery of fuel to the engine, or (c) preventing delivery of oxygen to the engine.
Flex Fuel Field Generator
Application
#2013016 Jul 4, 2013
Filed
Jan 4, 2012
Inventor
Larry J. Markoski (Raleigh, NC) ·
Larry J. Markoski (Raleigh, NC)
Appl. No.
13/343597
Assignee
Larry J. Markoski (Raleigh, NC) ·
Larry J. Markoski (Raleigh, NC)
International Classification
H02J 7/32, F02D 29/06, F02B 63/04
U.S. Classification
290 1 A, 320107, 290 2, 290 40 D
Abstract
A generator system includes (i) an internal combustion engine, (ii) an exhaust gas outlet, connected to the internal combustion engine, for venting exhaust gasses, and (iii) a condenser, connected to the exhaust gas outlet, for condensing water from exhaust gasses.
A fuel cell is described. The fuel cell includes current collectors, each of which includes a substrate of lightweight material, such as Kapton material. Micro channels are formed via laser machining or chemical etching into the substrate. The current collectors further include conductive layers sputtered on the substrate, and protective coating on the conductive layers. A variety of materials are available for the conductive layers. The fuel cell so developed is particularly well suited to mobile applications, such as electronic devices.
A fuel cell includes an anode including an anode catalyst, a cathode including a gas diffusion electrode and a cathode catalyst on the gas diffusion electrode, a channel that is contiguous with the anode, and a liquid including a fuel in the channel. The anode is in convective contact with the fuel, and the fuel cell has a fuel efficiency of at least 50%.
A fuel cell is described. The fuel cell includes current collectors, each of which includes a substrate of lightweight material, such as Kapton material. Micro channels are formed via laser machining or chemical etching into the substrate. The current collectors further include conductive layers sputtered on the substrate, and protective coating on the conductive layers. A variety of materials are available for the conductive layers. The fuel cell so developed is particularly well suited to mobile applications, such as electronic devices.
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.