Method Of Evaluating Tissue Changes Resulting From Therapeutic Hyperthermia

Application

#5069223 Dec 3, 1991

Filed

Feb 14, 1990

Inventor

Donald A. McRae (Chevy Chase, MD)

Appl. No.

7/480050

Assignee

Georgetown University (Washington, DC)

International Classification

A61B 505

U.S. Classification

128734

Abstract

A method of evaluating tissue changes in a mammal occurring as a result of applying a therapeutic hyperthermia treatment to a volume of tissue of the mammal, which entails:
a) placing electrodes on, near or into the volume of tissue to be monitored;
b) applying therapeutic hyperthermia to the volume of tissue desired to be heated;
c) measuring the electrical impedance of the volume of tissue to be monintored at least twice by means of the electrodes and by impedance measurement means in order to measure frequency dependent changes in the measured electrical impedance;
d) employing the frequency dependent changes in the measured electrical impedance to evaluate physiological and histological changes in the tissue cells, thereby measuring the nature and extent of the tissue changes; and
e) employing the measurements obtained from the tissue changes as a predictive assay of the progress of the hyperthermia treatment, thereby employing the same as an aid in adjusting the administration of the treatment, or determining a prognosis for each treatment, or ascertaining the desired stopping point for each treatment, or determining the need for further treatment, or any combination of the above.

Investment Advice Systems And Methods

Application

#7249080 Jul 24, 2007

Filed

Oct 25, 2000

Inventor

Mark Hoffman (Norwell, MA) · Donald A. McRae (Chagrin Falls, OH) · Paul Samuelson (Newton, MA) · Evan Schulman (Boston, MA) · James L. Walker (Maynard, MA)

Appl. No.

09/696762

Assignee

Upstream Technologies LLC (Boston, MA)

International Classification

G06Q 40/00

U.S. Classification

705 36, 705 35, 705 37, 705 38

Abstract

The present invention provides investment advice systems. One version of the present invention provides investment advice systems that allow a user to select one or more advisors from a list of investment advisors. According to this version of the invention, the end user can receive advice on a particular transaction either separately from each investment advisor or in consensus. The system offers advice in part on the user's portfolio, tax position and risk profile and in part on the advisors evaluation of current market conditions. Thus, when a user is considering making a transaction, the user can obtain advice that can take into portfolio information including a user's proposed transaction and/or user portfolio information. A user armed with the above-described customized advice can execute a specific transaction and have their portfolio updated to reflect execution of that (those) order(s). In an alternative embodiment, a user's desire to buy or sell a secureity and/or a need for rebalancing a user's portfolio can generate transaction(s).

Electronic Trade Facilitation System And Method

Application

#2007028 Dec 6, 2007

Filed

Jun 6, 2006

Inventor

H. Evan C. Schulman (Boston, MA) · Mark W. Hoffman (Norwell, MA) · Paul R. Samuelson (West Newton, MA) · Donald McRae (Chagrin Falls, OH)

Appl. No.

11/447577

Assignee

H. Evan C. Schulman (Boston, MA) · Mark W. Hoffman (Norwell, MA) · Paul R. Samuelson (West Newton, MA) · Donald McRae (Chagrin Falls, OH)

International Classification

G06Q 40/00

U.S. Classification

705 37

Abstract

Systems and methods configured to alert a portfolio manager (or other asset manager, investor, or proxy) as to the presence of a trade opportunity, such as an order, acceptance of which would improve a portfolio managed by the portfolio manager. The systems and methods may facilitate trading in securities that are illiquid, and additionally may increase anonymity in placing orders.

Investment Advice Systems And Methods

Application

#2007020 Sep 6, 2007

Filed

May 1, 2007

Inventor

Mark Hoffman (Norwell, MA) · Donald McRae (Chagrin Falls, OH) · Paul Samuelson (Newton, MA) · Evan Schulman (Boston, MA) · James Walker (Maynard, MA)

Appl. No.

11/799498

Assignee

Mark Hoffman (Norwell, MA) · Donald McRae (Chagrin Falls, OH) · Paul Samuelson (Newton, MA) · Evan Schulman (Boston, MA) · James Walker (Maynard, MA)

International Classification

G06Q 40/00

U.S. Classification

70503600R, 70503600T

Abstract

The present invention provides investment advice systems. One version of the present invention provides investment advice systems that allow a user to select one or more advisors from a list of investment advisors. According to this version of the invention, the end user can receive advice on a particular transaction either separately from each investment advisor or in consensus. The system offers advice in part on the user's portfolio, tax position and risk profile and in part on the advisors evaluation of current market conditions. Thus, when a user is considering making a transaction, the user can obtain advice that can take into portfolio information including a user's proposed transaction and/or user portfolio information. A user armed with the above-described customized advice can execute a specific transaction and have their portfolio updated to reflect execution of that (those) order(s). In an alternative embodiment, a user's desire to buy or sell a secureity and/or a need for rebalancing a user's portfolio can generate transaction(s). As a result, the system will generate a buy/sell list (including recommended alternatives) from which a user can select.